Angelo Paci Selected Research

Isocitrate Dehydrogenase (Isocitrate Dehydrogenase (NAD+))

1/2018	Circulating oncometabolite D-2-hydroxyglutarate enantiomer is a surrogate marker of isocitrate dehydrogenase-mutated intrahepatic cholangiocarcinomas.
12/2016	The IDH2 R172K mutation associated with angioimmunoblastic T-cell lymphoma produces 2HG in T cells and impacts lymphoid development.
12/2016	Familial hematological malignancies: new IDH2 mutation.
6/2016	Quantitation of isocitrate dehydrogenase (IDH)-induced D and L enantiomers of 2-hydroxyglutaric acid in biological fluids by a fully validated liquid tandem mass spectrometry method, suitable for clinical applications.

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Angelo Paci Research Topics

Disease

48	Neoplasms (Cancer) 01/2022 - 05/2004
9	Adrenocortical Carcinoma 03/2020 - 09/2010
5	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 12/2020 - 11/2006
5	Hematologic Neoplasms (Hematological Malignancy) 01/2017 - 03/2013
3	Body Weight (Weight, Body) 03/2021 - 04/2012
3	Necrosis 07/2015 - 02/2012
2	Oncogene Addiction 10/2021 - 12/2020
2	Sarcoma (Soft Tissue Sarcoma) 09/2021 - 12/2020
2	Renal Cell Carcinoma (Grawitz Tumor) 09/2021 - 01/2021
2	Germ Cell and Embryonal Neoplasms (Germ Cell Tumor) 01/2021 - 12/2017
2	Glioma (Gliomas) 01/2020 - 06/2014
2	Dyslipidemias (Dyslipidemia) 06/2019 - 01/2016
2	Oral Ulcer (Mouth Ulcer) 12/2017 - 10/2011
2	Thrombocytopenia (Thrombopenia) 01/2017 - 10/2010
2	Nausea 01/2017 - 02/2013
2	Fatigue 01/2017 - 02/2013
2	Neutropenia 01/2017 - 10/2010
2	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 01/2017 - 12/2016
2	Iron Overload 01/2016 - 04/2012
1	Inflammation (Inflammations) 01/2022
1	Reperfusion Injury 01/2022
1	Hepatocellular Carcinoma (Hepatoma) 03/2020
1	Testicular Neoplasms (Testicular Cancer) 03/2020
1	Disease Progression 01/2020
1	Breast Neoplasms (Breast Cancer) 01/2020
1	Diarrhea 01/2019
1	Dihydropyrimidine Dehydrogenase Deficiency 04/2018
1	Cholangiocarcinoma 01/2018
1	Myeloid Sarcoma (Chloroma) 01/2018
1	Hyperthermia 10/2017
1	Lymphopenia (Lymphocytopenia) 01/2017

Drug/Important Bio-Agent (IBA)

9	Pharmaceutical PreparationsIBA 09/2021 - 12/2012
8	Mitotane (Lysodren)FDA Link 06/2019 - 09/2010
6	EnzymesIBA 01/2022 - 08/2010
5	Cyclophosphamide (Cytoxan)FDA LinkGeneric 03/2021 - 06/2005
5	Busulfan (Busulfex)FDA Link 01/2016 - 02/2007
4	Monoclonal AntibodiesIBA 01/2022 - 05/2018
4	Biomarkers (Surrogate Marker)IBA 01/2019 - 01/2017
4	Isocitrate Dehydrogenase (Isocitrate Dehydrogenase (NAD+))IBA 01/2018 - 06/2016
4	Alkylating AgentsIBA 11/2017 - 06/2005
4	Melphalan (Alkeran)FDA LinkGeneric 01/2016 - 02/2012
3	Phosphotransferases (Kinase)IBA 09/2021 - 01/2017
3	Carboplatin (JM8)FDA LinkGeneric 01/2021 - 03/2014
3	Irinotecan (Camptosar)FDA LinkGeneric 01/2019 - 12/2012
3	alpha-hydroxyglutarateIBA 01/2018 - 06/2016
3	Gemcitabine FDA Link 01/2017 - 10/2007
2	Immune Checkpoint InhibitorsIBA 01/2022 - 01/2020
2	Tyrosine Kinase InhibitorsIBA 01/2021 - 01/2020
2	AntibodiesIBA 03/2020 - 01/2019
2	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 06/2019 - 08/2015
2	CrizotinibIBA 04/2019 - 01/2019
2	Everolimus FDA Link 12/2017 - 10/2011
2	Ifosfamide FDA LinkGeneric 11/2017 - 02/2009
2	Paclitaxel (Taxol)FDA LinkGeneric 10/2017 - 12/2012
2	Imatinib Mesylate (Gleevec)FDA Link 02/2013 - 02/2013
2	ProdrugsIBA 08/2010 - 02/2009
1	Succinate Dehydrogenase (Fumarate Reductase)IBA 01/2022
1	Succinic Acid (Succinate)IBA 01/2022
1	pazopanib FDA Link 09/2021
1	cabozantinibIBA 01/2021
1	Proton Pump InhibitorsIBA 01/2021
1	Anaplastic Lymphoma KinaseIBA 12/2020
1	Steroidogenic Factor 1IBA 03/2020
1	AntigensIBA 03/2020
1	AutoantibodiesIBA 03/2020
1	Tamoxifen FDA LinkGeneric 01/2020
1	Butyrates (Butyrate)IBA 01/2020
1	nilotinib FDA Link 01/2020
1	Vinblastine (Vinblastine Sulfate)FDA Link 01/2020
1	Volatile Fatty AcidsIBA 01/2020
1	Rosuvastatin Calcium (Crestor)FDA Link 06/2019
1	VaccinesIBA 01/2019
1	Cisplatin (Platino)FDA LinkGeneric 01/2019
1	GlucuronidaseIBA 01/2019
1	CarcinogensIBA 01/2019
1	Oxaliplatin (Eloxatin)FDA LinkGeneric 05/2018
1	EmulsionsIBA 05/2018
1	Ethiodized Oil (Ethiodol)FDA Link 05/2018
1	Capecitabine (Xeloda)FDA Link 04/2018
1	Fluorouracil (Carac)FDA LinkGeneric 04/2018
1	UracilIBA 04/2018
1	dihydrouracilIBA 04/2018
1	Colchicine FDA LinkGeneric 12/2017
1	trofosfamideIBA 11/2017
1	NanocapsulesIBA 10/2017
1	Alanine Transaminase (SGPT)IBA 01/2017
1	enasidenibIBA 01/2017
1	70-kDa Ribosomal Protein S6 Kinases (Ribosomal Protein S6 Kinases, 70 kDa)IBA 01/2017
1	Transaminases (Aminotransferases)IBA 01/2017
1	Alkaline PhosphataseIBA 01/2017
1	isocitric acid (isocitrate)IBA 01/2017
1	Oxidoreductases (Dehydrogenase)IBA 01/2017

Therapy/Procedure

9	Therapeutics 10/2021 - 10/2010
9	Drug Therapy (Chemotherapy) 01/2021 - 06/2005
3	Immunotherapy 01/2019 - 06/2005
3	Hematopoietic Stem Cell Transplantation 03/2013 - 04/2012
1	JET protocol 01/2021
1	Immunomodulation 01/2020
1	Combination Drug Therapy (Combination Chemotherapy) 02/2017
1	Highly Active Antiretroviral Therapy (HAART) 01/2017